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Skyrizi Infusion Therapy

Discover why thousands of patients choose Haven Infusion as their preferred place to receive infusions and injections.

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What is Skyrizi?

Skyrizi (risankizumab-rzaa) is an FDA-approved treatment for:

moderate-to-severe plaque psoriasis in adults who are candidates for systemic therapy or phototherapy
active psoriatic arthritis in adults
moderately to severely active Crohn's disease in adults
moderately to severely active ulcerative colitis in adults

Skyrizi works by targeting a specific protein in the immune system (interleukin-23) that contributes to inflammation, helping to reduce symptoms and improve skin or gut health.

For patients with Crohn’s disease or ulcerative colitis, Skyrizi is delivered as a combination of infusions and at-home injections. For patients with plaque psoriasis or psoriatic arthritis, Skyrizi is an at-home injection.

How Often Do I Need Skyrizi Infusions?

For patients with Crohn’s disease or ulcerative colitis, patients typically receive three Skyrizi doses by IV, once every 4 weeks. Then, they transition to at-home injections once every 8 weeks.

Each appointment typically takes 1.5-2.5 hours. The time is broken down approximately as follows:

Check-in & forms: ~10-15 min
Preparation: ~5–10 min
Medication administration: ~60-120 mins (shorter if Crohn’s; longer if ulcerative colitis)
Post-treatment monitoring: ~15-30 min (if required)

How Do I Prepare for My Skyrizi Infusion?

Here’s how you should prepare for your appointment:

Consult Your Healthcare Provider

Medical History Review: Ensure your healthcare provider has a complete and up-to-date medical history, including any allergies, current medications, and past reactions to other medications. Your doctor will have sent these records to Haven Infusion beforehand.
Pre-Appointment Testing: Complete any required blood tests or other pre-appointment tests as recommended by your healthcare provider.

Pre-Infusion Medications

Prescription Pre-Medications: You may require pre-medications to reduce the risk of a reaction or adverse event. Your referring provider will include any pre-medications when sending in your prescription order to Haven. Your Haven Infusion clinician will have these ready for you as part of your appointment.
Regular Medications: If you take other medications on a regular basis, be sure to consult with your doctor to see if you need to change how you take them while on Skyrizi.

Hydration and Nutrition

Hydrate: Drink plenty of water in the days leading up to your infusion to ensure you are well-hydrated. If you are a regular caffeine drinker, go lighter the morning of, since caffeine is dehydrating.
Eat Light: Have a light meal before your infusion to help maintain your energy levels during the procedure.
Prepare for Comfort
Clothing: Wear loose, comfortable clothing with easy access to your arms for the infusion site.
Entertainment: Bring whatever you would like to keep you occupied, such as a book, tablet, or music.

Plan for Transportation

Arrange a Ride: Depending on the medication and your reaction to the infusion, you might not feel well enough to drive yourself home. Consider arranging for someone to drive you or use a ride service.

By following these steps, you can help ensure that your infusion is as safe and comfortable as possible. Always follow the specific instructions provided by your healthcare team.

Does Skyrizi Have Any Side Effects?

Most patients tolerate Skyrizi well. If a patient does have side effects, the most common ones are cold-like symptoms, headache or fatigue.

If you have concerns about side effects, please feel free to discuss them with your doctor before starting treatment. As a specialist in infusion care, Haven Infusion operates with comprehensive and well-established safety protocols, and we are happy to share them with you.

How Much Does Skyrizi Cost?

Coverage varies depending on your insurance plan. Our goal is to lower your out-of-pocket costs as much as possible. When your doctor sends us your information, we will verify your benefits and help you find assistance programs that you qualify for.

We always review your expected out-of-pocket costs with you before scheduling your first appointment to ensure full transparency. And, if you have any questions or need help understanding how your insurance works, feel free to ask.