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Briumvi Infusion Therapy

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What is Briumvi?

Briumvi (ublituximab-xiiy) is prescription biologic therapy used to treat certain relapsing forms of multiple sclerosis in adults, including:

Clinically isolated syndrome
Relapsing-remitting MS
Active secondary progressive MS

It is a CD-20-targeting monoclonal antibody that works by gently reducing certain immune cells (B cells) to help slow disease activity and reduce the risk of relapse.

How Often Do I Need Briumvi Infusions?

Patients typically receive their first Briumvi infusion on a smaller dose, then their second infusion 2 weeks later at a higher dose. Further infusions are done every 6 months thereafter at that higher dose.

The first appointment is about 5 hours. Future appointments are about 2 hours. Here’s the breakdown:

Check-in & forms: ~10-15 min
Preparation: ~5–10 min
Medication administration: 4 hours for first infusion; 1 hour for further infusions
Post-treatment monitoring: ~15-30 min (if needed)

How Do I Prepare for My Briumvi Infusion?

Here’s how you should prepare for your appointment:

Consult Your Healthcare Provider

Medical History Review: Ensure your healthcare provider has a complete and up-to-date medical history, including any allergies, current medications, and past reactions to other medications. Your doctor will have sent these records to Haven Infusion beforehand.
Pre-Appointment Testing: Complete any required blood tests or other pre-appointment tests as recommended by your healthcare provider. For Briumvi, these may include Hepatitis B and serum immunoglobulin screenings.

Pre-Infusion Medications

Prescription Pre-Medications: You may require pre-medications to reduce the risk of a reaction or adverse event. Your referring provider will include any pre-medications when sending in your prescription order to Haven. Your Haven Infusion clinician will have these ready for you as part of your appointment.
Regular Medications: If you take other medications on a regular basis, be sure to consult with your doctor to see if you need to change how you take them while on Briumvi.

Hydration and Nutrition

Hydrate: Drink plenty of water in the days leading up to your infusion to ensure you are well-hydrated. If you are a regular caffeine drinker, go lighter the morning of, since caffeine is dehydrating.
Eat Light: Have a light meal before your infusion to help maintain your energy levels during the procedure.
Prepare for Comfort
Clothing: Wear loose, comfortable clothing with easy access to your arms for the infusion site.
Entertainment: Bring whatever you would like to keep you occupied, such as a book, tablet, or music.

Plan for Transportation

Arrange a Ride: Depending on the medication and your reaction to the infusion, you might not feel well enough to drive yourself home. Consider arranging for someone to drive you or use a ride service.

By following these steps, you can help ensure that your infusion is as safe and comfortable as possible. Always follow the specific instructions provided by your healthcare team.

Does Briumvi Have Any Side Effects?

Most patients tolerate Briumvi well. If a patient does have side effects, the most common ones are flu- or cold-like symptoms, insomnia or fatigue.

If you have concerns about side effects, please feel free to discuss them with your doctor before starting treatment. As a specialist in infusion care, Haven Infusion operates with comprehensive and well-established safety protocols, and we are happy to share them with you.

How Much Does Briumvi Cost?

Coverage varies depending on your insurance plan. Our goal is to lower your out-of-pocket costs as much as possible. When your doctor sends us your information, we will verify your benefits and help you find assistance programs that you qualify for.

We always review your expected out-of-pocket costs with you before scheduling your first appointment to ensure full transparency. And, if you have any questions or need help understanding how your insurance works, feel free to ask.